A Role for Thyroid Hormone Transporters in Transcriptional Regulation by Thyroid Hormone Receptors

Regulation of fibronectin by thyroid hormone receptors.

Thyroid hormones regulate growth, development, differentiation, and metabolic processes by interacting with and activating thyroid hormone receptors and associated pathways. We investigated the triiodothyronine (T3) modulation of gene expression, in human hepatocellular carcinoma cell lines, via a PCR-based cDNA subtraction method. Here we present further data on one of the T3-upregulated genes...

Regulation of thyroid hormone-induced development in vivo by thyroid hormone transporters and cytosolic binding proteins.

Differential tissue sensitivity/responsivity to hormones can explain developmental asynchrony among hormone-dependent events despite equivalent exposure of each tissue to circulating hormone levels. A dramatic vertebrate example is during frog metamorphosis, where transformation of the hind limb, brain, intestine, liver, and tail are completely dependent on thyroid hormone (TH) but occurs async...

Transcriptional regulation by nonclassical action of thyroid hormone

Thyroid hormone (TH) is essential for normal development, growth and metabolism. Its effects were thought to be principally mediated through triiodothyronine (T3), acting as a ligand for the nuclear TH receptors (TRs) α and β residing on thyroid hormone response elements (TREs) in the promoter of TH target genes. In this classical model of TH action, T3 binding to TRs leads to recruitment of ba...

Regulation of Gene Transcription by the Thyroid Hormone Receptors

Thyroid hormone transporters in the human.

Corresponding Authors: Anastasios Papadimitriou, MD, 3 Department of Pediatrics, University of Athens School of Medicine, “Attikon” University Hospital, 1 Rimini Street, 124 64 Athens, Greece, Tel: +30-210-5832046, Fax:+30-210-5832229, e-mail: [email protected] Received 31-08-11, Revised 08-09-11, Accepted 25-09-11